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In some cases the adrenal response to the systemic dose of steroids might be minimal without any significant response in the internal organs. Steroids with no activity such as the non-bioactive steroid pregnenolone have been used for treatment of fibrosing ulcers in patients with AIDS, without effect. The fact that steroids in this category can cause liver damage is often ignored. Such a case should give much concern to patients and their health-care providers, clenbuterol weight loss 2021. For this reason, the current position statement of the United States Public Health Service on androgenic steroid abuse states that the therapeutic threshold has not been empirically defined and therefore it is not possible to recommend or refuse to treat patients with low-dose androgenic steroids without a rigorous epidemiologic evaluation.
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